Cialis(Tadalafil)

Tadalafil sold most notably under the brand name of CIALIS is a medication used to treat Erectile Dysfunction(ED), benign prostatic hyperplasia, and pulmonary arterial hypertension. It is a tablet taken by mouth. Tadalafil relaxes muscles of the blood vessels and increases blood flow to particular areas of the body.

Tadalafil acts by inhibiting the PDE5 enzyme, but these drugs also inhibit PDE enzymes 6, 1, and 11 in varying degrees.

Tadalafil in Treating Erectile Dysfunction

Tadalafil once-daily is FDA-approved for ED, for sale in 2.5, 5, 10, and 20 mg strengths. The price of the 5 mg and 2.5 mg are often similar, so some people score and split the pill.

Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and the smooth muscle of the corpus cavernosum. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cyclic guanosine monophosphate (more commonly known as cyclic GMP or cGMP) in smooth muscle cells. cGMP relaxes smooth muscle and increases blood flow to the corpus cavernosum.

The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil (as well as Sildenafil [Viagra] and Vardenafil [Levitra]) inhibits PDE5. However, because sexual stimulation is required to initiate the local penile release of nitric oxide, tadalafil’s inhibition of PDE5 will have no effect without direct sexual stimulation of the penis.

Tadalafil for Use as Needed for Erectile Dysfunction

  • The recommended starting dose of Tadalafil for use as needed in most patients is 10 mg, taken prior to anticipated sexual activity.
  • The dose may be increased to 20 mg or decreased to 5 mg, based on individual efficacy and tolerability. The maximum recommended dosing frequency is once per day in most patients.
  • Tadalafil for use as needed was shown to improve erectile function compared to placebo up to 36 hours following dosing. Therefore, when advising patients on optimal use of Tadalafil(CIALIS), this should be taken into consideration.

Tadalafil for Once Daily Use for Erectile Dysfunction

  • The recommended starting dose of Tadalafil for once daily use is 2.5 mg, taken at approximately the same time every day, without regard to timing of sexual activity.
  • The Tadalafil dose for once daily use may be increased to 5 mg, based on individual efficacy and tolerability.

How long does Tadalafil take to work?

Tadalafil works fairly quickly to treat your ED, BPH symptoms, or both conditions. Studies show that the medication may work as quickly as 30 minutes after you take your dose. However, in some people, the medication may take up to 6 hours until you notice it working. On average, it takes about 2 hours for Tadalafil(CIALIS) to the peak.

How long will Tadalafil stay in my system?

Although Tadalafil,  Vardenafil, and Sildenafil all work by inhibiting PDE5, Tadalafil’s pharmacologic distinction is its longer half-life (17.5 hours), compared to Sildenafil and Vardenafil, which are both 4–5 hours. This translates to a longer duration of action, which is partly responsible for “The Weekend Pill” nickname. Furthermore, the longer half-life is the basis for tadalafil’s daily therapeutic use in treating pulmonary arterial hypertension.

Can I directly order Tadalafil online?

Because you need a prescription for ordering Tadalafil, up until recently this required an in-person visit to the doctor. It is now so much easier. If you feel uncomfortable about the visiting doctor, you can try the free consultation provided by “The ED Clinic”.“The ED Clinic” offers a variety of medication and simple on-line intake. Get your erectile dysfunction issue in front of some of the best physicians in the field from the comfort of your own home.

2 Comments on “What is Tadalafil(CIALIS)?”

  1. Pingback: FAQS about Cialis(Tadalafil)[24 must-read questions before taking Cialis]

  2. Pingback: Are Erectile Dysfunction(ED) Medications available online safe to use?

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