Erectile dysfunction is one of the most common sexual dysfunctions in men and Viagra is one of the popular drugs used in treating erectile dysfunction.
Viagra is available in three dosages 25mg, 50mg, and 100 mg.
The prescribing information for sildenafil citrate recommends flexible dosing (50 mg initially, adjusted to 100 or 25 mg based on effectiveness and tolerability) in most men with erectile dysfunction (ED). In many men, however, 100 mg may be the most appropriate initial dose because it would reduce the need for titration and could prevent discouragement, and treatment abandonment should 50 mg be insufficient.
Which viagra dose worked better?
For most men with erectile dysfunction (ED), the prescribing information for sildenafil citrate (VIAGRA, Pfizer) recommends an initial dose of 50 mg, increased to 100 mg or decreased to 25 mg based on effectiveness and tolerability (flexible dose). However, 100 mg sildenafil produced optimal erection hardness (fully hard and rigid) in a substantial proportion of men with ED. In addition, in dose-optimization studies and at the end of double-blind, placebo-controlled (DBPC) treatment in recent reports of flexible-dose trials, 100 mg was the dose that was used by most men. Thus, the 100-mg dose may provide some additional benefit beyond that achieved with the 50-mg dose and maybe the most appropriate choice for initiation of therapy in many men.
Comparison between 50mg and 100mg Viagra dosages in terms of Hardness, function, emotional well-being, satisfaction, and the overall sexual experience
As reported previously, sildenafil, whether initiated at a fixed dose of 50 or 100 mg, or at a dose of 50 mg and titrated as needed up to 100 mg, was significantly more effective than placebo in the treatment of ED, and there were additional benefits to the use of 100 mg fixed-dose sildenafil compared with 50 mg fixed-dose sildenafil.
For the 100-mg fixed-dose regimen relative to the flexible-dose regimen, there was a similar increase from baseline in the percentage of erections.
Approximately one-third more men in the 100-mg fixed-dose vs the flexible-dose(50 mg) regimen were satisfied with their sildenafil treatment. The similarity in outcomes between the two regimens is not surprising given that almost 90% of the men who initiated treatment with flexible-dose sildenafil titrated to a dose of 100 mg after 2 weeks.
Given that almost 90% of the men who initiated treatment with flexible-dose sildenafil titrated to a dose of 100 mg after 2 weeks, initiating treatment with 100-mg sildenafil should greatly decrease the need for dose titration and, in those men for whom a dose of 50 mg might prove ineffective, may decrease the risk of discouragement and treatment abandonment because of inadequate dosing. The high proportion of men titrating to a dose of 100 mg supports earlier results, which showed that 100-mg sildenafil produced optimal erection hardness (fully hard and rigid) in a substantial proportion of men with ED and that 100 mg was the dose used by most men in dose-optimization studies.
An initial dose of sildenafil 100 mg may not be appropriate in some men. For example, higher plasma concentrations of sildenafil than those seen in healthy young volunteers occurred in men aged >65 years, in those who have a hepatic impairment or severe renal impairment, and in those using concomitant potent cytochrome P450 3A4 inhibitors.
In addition, men with left ventricular outflow obstruction (for example, aortic stenosis, idiopathic hypertrophic subaortic stenosis) and those with severely impaired autonomic control of blood pressure can be particularly sensitive to the actions of vasodilators, including sildenafil.1 When sildenafil is coadministered with an α-blocker, patients should be stable on α-blocker therapy before initiating sildenafil treatment, and sildenafil should be initiated at the lowest dose.
In conclusion, sildenafil in doses of 50 and 100 mg is effective for the treatment of ED, and both doses are generally well tolerated. An initial dose of sildenafil 100 mg appears to be at least as efficacious and well-tolerated as an initial dose of 50 mg with the option to titrate to the optimal dose. Furthermore, an initial dose of 100 mg may reduce the need for dose titration and may prevent discouragement and treatment abandonment in men for whom a dose of 50 mg is insufficient.
Anyways consulting a doctor is always better and consulting a doctor can reveal the reason for your erectile dysfunction and “The ED Clinic” is offering a free consultation with the best doctors in the field. Men need to muster up the courage to seek professional help from a doctor or a qualified clinical sexologist. Just taking this step will get them on their way to recover not only their sex life but their relationship as well. They need not worry about their privacy as clinics like “The ED Clinic” take full care to make sure all privacy details are just that- Private.